Benzodiazepine poisoning antidote4/10/2023 ![]() In the United States, the local Regional Poison Control Center may be reached at 80. Total iron-binding capacity may be falsely elevated in patients with acute iron overdose and is not a reliable marker in iron toxicity. Succinylcholine is relatively contraindicated in cholinesterase inhibitor toxicity because its duration of effect will be significantly prolonged. Serum toxic alcohol levels are the gold standard for diagnosis and prognosis. Malignant hyperthermia, serotonin syndrome, neuroleptic malignant syndrome, sympathomimetic poisoning, and anticholinergic poisoning constitute the major differential diagnosis for xenobiotic-induced hyperthermia.Īn elevated osmolar gap may suggest ingestion of a toxic alcohol, but a normal result does not exclude it. Use the skin to distinguish between sympathomimetic (pale, cool, and diaphoretic) and anticholinergic (flushed, warm, and dry) toxidromes. ![]() Pulse oximetry is unreliable for determining oxygen saturation with methemoglobinemia and may show falsely elevated or decreased values. ![]() ![]() It is contraindicated for reversal of anticholinergic symptoms produced by tricyclic antidepressant ingestion. Reserve physostigmine administration for severe, life-threatening manifestations of anticholinergic toxicity because it may lead to asystole or seizures. Β-Adrenergic antagonists, when used to lower blood pressure in a sympathomimetic overdose, may lead to unopposed α-receptor stimulation and should be avoided. Flumazenil, when used for benzodiazepine overdose, may unmask seizures caused by a coingested substance or precipitate acute withdrawal in the patient who habitually uses benzodiazepines.
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